Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Names and Identifiers

Name	nicergoline
Synonyms	FI 6714 Cergodum RP 19651 Dilasenil Nicergolin NSC 150531 Duracebrol BRN 4828393 Nimergoline nicergoline Nicergolina Circo-Maren Nicergolinum Nicotergoline UNII-JCV8365FWN nicergoline Fr.P Nimergoline base Nicergolina [DCIT] Nicergolin [German] Nicergolinum [INN-Latin] 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether 10-Methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinate 1,6-Dimethyl-8b-(5-bromonicotinoyloxymethyl)-10a-methoxyergoline 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester) (10-methoxy-1,6-dimethylergolin-8-yl)methyl 5-bromopyridine-3-carboxylate 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German] 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) [(8beta)-10-methoxy-1,6-dimethylergolin-8-yl]methyl 5-bromopyridine-3-carboxylate 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester) Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI) [(8beta)-10-methoxy-1,6-dimethylergolin-6-ium-8-yl]methyl 5-bromopyridine-3-carboxylate Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester) Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester) Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8.beta.)-
CAS	27848-84-6
EINECS	248-694-6
InChI	InChI=1/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/p+1/t15-,21-,24+/m1/s1

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Physico-chemical Properties

Molecular Formula	C24H26BrN3O3
Molar Mass	484.39
Density	1.3558 (rough estimate)
Melting Point	136-138°
Boling Point	594.4±50.0 °C(Predicted)
Flash Point	313.252°C
Water Solubility	Soluble in alcohol, chloroform, and acetone. Insoluble in water.
Solubility	Practically insoluble in water, freely soluble in methylene chloride, soluble in ethanol (96 per cent).
Vapor Presure	0mmHg at 25°C
Appearance	neat
Color	White to Off-White
Merck	14,9496
pKa	6.33±0.40(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.6200 (estimate)
In vitro study	Nicergoline (0.3-30 μM; 24 h) attenuates activated microglia- and astrocytes-induced neuronal cell death. Nicergoline (0.3-30 μM; 48 h) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia.

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Safety Description	36 - Wear suitable protective clothing.
UN IDs	1544
WGK Germany	3
RTECS	KE6341000
HS Code	29396100
Hazard Class	6.1(b)
Packing Group	III
Toxicity	LD50 in male mice, rats (mg/kg): 860, 2800 orally; 46, 43 i.v. (Neumann, Lauschner)

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.064 ml	10.322 ml	20.645 ml
5 mM	0.413 ml	2.064 ml	4.129 ml
10 mM	0.206 ml	1.032 ml	2.064 ml
5 mM	0.041 ml	0.206 ml	0.413 ml

Last Update：2024-01-02 23:10:35

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Reference Information

Overview	Nicergoline is a semi-synthetic ergot alkaloid derivative. Since successful research and development in the 2060s, it has been registered and used in more than 50 countries. It has also been widely used in cerebrovascular disease, dementia, dizziness and other diseases in China.
mechanism of action	improving cerebral circulation: nicergoline can dilate resistance blood vessels, thereby improving cerebral circulation. As a specific adrenaline α1 receptor blocker, the drug can inhibit the pressure reflex of the resistance blood vessels, increase the local cerebral blood flow and glucose utilization rate during the reperfusion period after bilateral internal carotid artery ligation in rats; reduce the blood pressure of anesthetized dogs, but does not affect the cerebral blood flow; and can improve the cerebral vasospasm induced by experimental subarachnoid hemorrhage in rabbits. Improve brain metabolism and electrophysiological activities: Long-term treatment of nicergoline can improve the glucose utilization rate of brain extracts in aged rats. Acute medication can improve the memory function of elderly subjects, increase the total energy of EEG topography, and reduce slow waves.
Biological activity	Nicergoline, ergoline derivative of bromotinic acid, is an effective, selective and orally active α1A-adrenergic receptor antagonist. Nicergoline have vasodilatory effects. Nicergoline can improve the cognitive function of Alzheimer's mice.
Target	Value
Animal Model:	3×Tg-AD mice (male, 28-35 g, 6 weeks) with the Alzheimer's disease
Dosage:	10 mg/kg
Administration:	I.v. once daily for 60 days
Result:	Improved neurogenesis and cognitive competence. Decreased the degree of dementia. Downregulated pathogenic Aβ-42 and -40 peptides and APP in the hippocampi. Increased Levels of the neuroprotective forkhead box protein P2 (Foxp2), Src homology 2-containing inositol phosphatase (SxIP) and end-binding proteins (EB) in the hippocampi. Exhibited marked differences in the dispersion of the pyramidal cell layer between the nicergoline-treated and control groups.

Last Update：2024-04-10 22:29:15

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-

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View History

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
1-[4-(丙-2-基)苯基]丙-1-胺
290819-03-3
4-二胺基酪酸
(1-Formyl-1-nitro-2-oxoethyl) monohydrate sodium, 3-Hydroxy-2-nitro-2-propenal monohydrate sodium salt, 3-Hydroxy-2-nitroacrolein monohydrate sodium salt, Sodium nitromalondialdehyde monohydrate, Sodium nitromalonic dialdehyde monohydrate, Sodium nitropropanedial monohydrate
ETHYL 1-(4-METHOXYBENZYL)-4-AMINO-1H-IMIDAZOLE-5-CARBOXYLATE(WXG01100)
2-Ethyl-6-methyl-3-hydroxypyridine succinate
iso-Octyl methacrylate

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-

nicergoline

CAS: 27848-84-6

Molecular Formula: C24H26BrN3O3

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Names and Identifiers

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Physico-chemical Properties

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Risk and Safety

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Preparation solution concentration reference

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Reference Information

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Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- Request for Quotation

nicergoline

CAS: 27848-84-6

Molecular Formula: C24H26BrN3O3

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Names and Identifiers

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Physico-chemical Properties

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Risk and Safety

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Preparation solution concentration reference

Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- - Reference Information

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Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-